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ea0060p15 | (1) | UKINETS2018

NETest liquid biopsy is diagnostic of lung neuroendocrine tumors and identifies progressive disease

Malczewska Anna , Kos-Kudla Beata , Filosso Pier-Luigi , Aslanian Harry , Lewczuk Anna , Cwikla Jaroslaw , Rofinella Mateo , Bodei Lisa

Background: There are no effective blood biomarkers for bronchopulmonary carcinoids (BPC). We examined the utility of a neuroendocrine multigene transcript liquid biopsy (NETest) in bronchopulmonary carcinoids (BPC) for diagnosis and monitoring of disease status.Aim: To independently validate the utility of the NETest in diagnosis and management of BPC in a prospective multicenter, multinational blinded study.Material a...

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ea0052p02 | (1) | UKINETS2017

Validation of a blood biomarker test for the diagnosis and management of bronchopulmonary neuroendocrine tumors

Modlin Irvin , Kidd Mark , Lewczuk Anna , Chung Kjung-Min , Kolasinska-Cwikla Agnieska , Cwikla Jaroslaw , Lowczak Anna , Doboszynska Anna , Tesselaar Margot , Buikhuisen Wieneke , Malczewska Anna , Kos-Kudla Beata , Roffinella Matteo , Filosso Pier Luigi , Korse Tiny , Papotti Mauro , Bodei Lisa , Drozdov Ignat

Background: There is currently no effective blood biomarker for lung neuroendocrine neoplasia diagnosis and management. We describe the clinical utility of a 51 neuroendocrine-specific gene expression set in blood to diagnose bronchopulmonary neuroendocrine tumors (BPNETs) and define their clinical status.Methods: The discovery set included BPNETs (n=154) and controls (n=90), randomly assigned (1:1) to a test and validation set. Specifi...

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Endocrine Abstracts

NETest liquid biopsy is diagnostic of lung neuroendocrine tumors and identifies progressive disease

Validation of a blood biomarker test for the diagnosis and management of bronchopulmonary neuroendocrine tumors

BiosciAbstracts